Latest Blog Posts

Gut microbiota modulate neurobehavior through changes in brain insulin sensitivity and metabolism

Obesity and diabetes in humans are associated with increased rates of anxiety and depression. To understand the role of the gut microbiome and brain insulin resistance in these disorders, we evaluated behaviors and insulin action in brain of mice with diet-induced obesity (DIO) with and without antibiotic treatment. We find that DIO mice have behaviors…

Diet Hit A Snag? Your Gut Bacteria May Be Partly To Blame

Have you ever been on a diet but didn’t hit your goal weight? Your gut bacteria may be part of the explanation. New research suggests the mix of microbes in our guts can either help — or hinder — weight-loss efforts. “We started with the premise that people have different microbial makeups, and this could…

Targeting the gut microbiome to treat the osteoarthritis of obesity

Obesity is a risk factor for osteoarthritis (OA), the greatest cause of disability in the US. The impact of obesity on OA is driven by systemic in ammation, and increased systemic in ammation is now understood to be caused by gut microbiome dysbiosis. Oligofructose, a nondigestible prebiotic ber, can restore a lean gut microbial community…

How Holobionts get Sick

Interesting article that continues the discussion of redeveloping our medical diagnostic and treatment paradigm to include dysbiosis.   Technologies such a multiplexing assays give us the ability to quickly gauge the absence or presence of certain complexes that create an environment for disease.  Additionally, the introduction of new vocabulary is essential to further discussions and…