Microbiome Restoration

  • Home
  • Our Microbiomes
  • Location
  • Blog
  • Contact Us
  • About Us
  • Microbiome Links
  • Microbiome Transplant
  • Microbes: How They Help Us
  • Education and Dictionary

Category Archives: Obesity

Gut microbiota modulate neurobehavior through changes in brain insulin sensitivity and metabolism

13th August, 2018 · rushman

Obesity and diabetes in humans are associated with increased rates of anxiety and depression. To understand the role of the gut microbiome and brain insulin resistance in these disorders, we evaluated behaviors and insulin action in brain of mice with diet-induced obesity (DIO) with and without antibiotic treatment. We find that DIO mice have behaviors reflective of increased anxiety and depression. This is associated with decreased insulin signaling and increased inflammation in the nucleus accumbens and amygdala. Treatment with oral metronidazole or vancomycin decreases inflammation, improves insulin signaling in the brain and reduces signs of anxiety and depression. These effects are associated with changes in the levels of tryptophan, GABA, BDNF, amino acids, and multiple acylcarnitines, and are transferable to germ-free mice by fecal transplant. Thus, changes in gut microbiota can control brain insulin signaling and metabolite levels, and this leads to altered neurobehaviors.

Download (PDF, 2.7MB)

Share this:

  • Print
  • Facebook
  • Twitter
Posted in microbiome, Obesity | Tags: insulin, obesity |

RSS ScienceDaily – Top Health Articles

  • Genome-editing tool TALEN outperforms CRISPR-Cas9 in tightly packed DNA
  • Pace of prehistoric human innovation could be revealed by 'linguistic thermometer'
  • Genetically-modified mosquitoes key to stopping Zika virus spread
  • A benchmark for single-electron circuits
  • Vaccine shows potential against deadly leptospirosis bacteria
  • Wirelessly rechargeable soft brain implant controls brain cells
  • New control mechanism in innate immune system
  • Gut microbiota reveals whether drug therapies work in inflammatory bowel diseases
  • Finding a way to stop chemotherapy from damaging the heart
  • Toddlers who use touchscreens may be more distractible

RSS Gastrointestinal Problems News — ScienceDaily

  • Gut microbiota reveals whether drug therapies work in inflammatory bowel diseases
  • Better post-surgery care would dramatically improve cancer survival
  • Vegan diet significantly remodels metabolism in young children
  • For some, GI tract may be vulnerable to COVID-19 infection
  • Fatty acid may help combat multiple sclerosis, study finds
  • Simple, cheap test can help save lives from colorectal cancer, study shows
  • Scientists reveal mechanism that causes irritable bowel syndrome
  • Feces and algorithms: Artificial Intelligence to map our intestinal bacteria
  • Poor gut health connected to severe COVID-19, new review shows
  • Researchers engineer novel disease model to identify potential targets for ulcerative colitis drugs
© Microbes R My Friends
  • Home
  • Our Microbiomes
  • Location
  • Blog
  • Contact Us
  • About Us
  • Microbiome Links
  • Microbiome Transplant
  • Microbes: How They Help Us
  • Education and Dictionary